Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, …
Regulation of Growth Factors, Cytokines, and Chemokines in Schwann Cells in Neuropathic Pain. In response to nerve injury, glial mediators produced or released by activated Schwann cells or recruited immune cells are also a key issue in the control of neuropathic pain by Schwann cells.
Specialized cutaneous Schwann cells initiate pain sensation
2019年8月16日 · We provide evidence for a specialized glial cell type that builds a sensory organ in the skin, initiating the sensation of pain. The nociceptive Schwann cells display a mesh-like network of cytoplasmic sheaths around nerves in the subepidermal border with radial processes entering into the epidermis abutting to unmyelinated nociceptive nerves.
Potential role of Schwann cells in neuropathic pain
2023年10月5日 · Schwann cells (SCs) form the myelin sheaths around neuronal axons and play a crucial role in neural information transmission. SCs can secrete trophic factors to nourish and protect axons, and can further secrete pain-related factors to induce pain.
SCHWANN CELLS: ACTIVATED PERIPHERAL GLIA AND THEIR ROLE IN NEUROPATHIC PAIN
In this review, I will discuss emerging evidence that Schwann cells play an important role in the development of neuropathic pain states. Understanding Schwann cell physiology, the response of Schwann cells to cytokines and other extracellular mediators, and the capacity of Schwann cells to express cytokines in a regulated manner emerges as a ...
Demise of nociceptive Schwann cells causes nerve retraction and pain …
2021年1月22日 · We find that their demise is sufficient to cause neuropathy and neuropathic pain. Keywords: Nociceptive Schwann cells, Nerve retraction, Pain hyperalgesia, Peripheral neuropathy. Recent findings indicate that nociceptive nerves are not “free”, but similar to touch and pressure sensitive nerves, terminate in an end-organ in mice.
Schwann Cells Key to Touch and Pain - Neuroscience News
2024年2月6日 · Schwann cells are instrumental in detecting sensory stimuli, working alongside sensory neurons to convey pain and touch sensations to the brain. The study utilized optogenetics to show that activating Schwann cells could induce pain sensations, and blocking them reduced stimulus transmission by at least half.
Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, …
2019年3月27日 · Schwann cells, which detect nerve injury and provide the first response, play a critical role in the development and maintenance of neuropathic pain. The cells respond to nerve injury by changing their phenotype, proliferating and interacting with nociceptive neurons by releasing glial mediators (growth factors, cytokines, chemokines, and ...
Potential role of Schwann cells in neuropathic pain
2023年10月5日 · Following nerve injury, activated Schwann cells secrete pain-related factors such as neurotrophic factors and cytokines to promote axon-glia communication, thereby altering the microenvironment around damaged neurons and …
Potential role of Schwann cells in neuropathic pain - PubMed
2023年10月5日 · Schwann cells (SCs) form the myelin sheaths around neuronal axons and play a crucial role in neural information transmission. SCs can secrete trophic factors to nourish and protect axons, and can further secrete pain-related factors to induce pain.
Frontiers | Emerging Role of Schwann Cells in Neuropathic Pain ...
2019年3月26日 · Regulation of Growth Factors, Cytokines, and Chemokines in Schwann Cells in Neuropathic Pain. In response to nerve injury, glial mediators produced or released by activated Schwann cells or recruited immune cells are also a key issue in the control of …