Acetylcholine receptor - Wikipedia
Nicotinic acetylcholine receptor structure Acetylcholine. An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
Acetylcholine Receptor Structure
2018年3月14日 · Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion …
Structural switch in acetylcholine receptors in developing muscle
2024年7月31日 · Here, we present high-resolution structures of both fetal and adult muscle nicotinic AChRs, isolated from bovine skeletal muscle in developmental transition.
The Structure, Function, and Physiology of the Fetal and Adult ...
2020年9月7日 · The muscle-type nicotinic acetylcholine receptor (AChR) is a key molecular component located at the postsynaptic muscle membrane responsible for the generation of the endplate potential (EPP), which usually exceeds the threshold potential necessary to activate voltage-gated sodium channels and triggers a muscle action potential.
END-PLATE ACETYLCHOLINE RECEPTOR: STRUCTURE, …
III. AChR STRUCTURE. Owing to the AChR’s large size, oligomeric quaternary structure and location within the cell membrane, structure determination by x-ray crystallography has remained elusive. Thus multidisciplinary approaches, both direct and indirect, have been brought to bear on AChR structure determination.
Ancestral Reconstruction Approach to Acetylcholine Receptor Structure …
2017年8月1日 · Our results outline a promising strategy for studies of AChR evolution aimed at identifying the amino acid origins of AChR structure and function. Billions of years of evolution have led to a staggering array of ion-channel diversity, with different ion-channel types opening and closing in response to a variety of stimuli (Hille, 2001).
Our results outline a promising strategy for studies of AChR evolution aimed at identifying the amino acid origins of AChR structure and function. Billions of years of evolution have led to a staggering array of ion-channel diversity, with different ion-channel types opening and closing in response to a variety of stimuli (Hille, 2001).
The nicotinic acetylcholine receptor: structure and autoimmune ...
The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.
AChR structure and function. A, the transmitter binding site. Left ...
The nicotinic acetylcholine receptor (AChR) is a ∼300 kD ion channel that binds the neurotransmitter acetylcholine (ACh) and other cholinergic agonists to elicit...
The Structure, Function, and Physiology of the Fetal and Adult ...
The muscle-type nicotinic acetylcholine receptor (AChR) is a key molecular component located at the postsynaptic muscle membrane responsible for the generation of the endplate potential (EPP), which usually exceeds the threshold potential necessary to activate voltage-gated sodium channels and triggers a muscle action potential.