Our understanding of hypertension and the ability to lower blood pressure (BP) with pharmacotherapy advanced immensely during the second half of the 20th century and the early 21st century. However, ...

Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA).

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BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to ...

View all available purchase options and get full access to this article. Wagner R, Heni M, Tabak AG, Machann J, Schick F, Randrianarisoa E, Hrabe de Angelis M, Birkenfeld AL, Stefan N, Peter A, et al.

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Cardiovascular diseases account for approximately 30% of deaths worldwide and remain a leading cause of morbidity and mortality globally, driving the need for ongoing major research investments. These ...

Classically, hypertrophic cardiomyopathy (HCM) has been viewed as a single-gene (monogenic) disease caused by pathogenic variants in sarcomere genes. Pathogenic sarcomere variants are individually ...