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基于亲电片段的表型与活性联合分析揭示抗生素作用靶点
确定的多个靶点中,FabH 是已知的抗生素靶点,10 - F05 对其抑制作用在革兰氏阴性菌中效果显著;MiaA 和 PdxY 则是此前未被认可的抗生素靶点,10 - F05 有望成为开发针对这些新靶点选择性抑制剂的基础。此外,10 - F05 的多靶点作用机制可能降低细菌耐药性的产生 ...
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