More than 100 million people in the U.S. will be in the path of an intense March storm starting Friday as the sprawling multi-day system threatens fires, blizzards, tornadoes, and flooding as it tracks eastward across the Great Plains.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.

At least 17 people have been killed in a monster storm sweeping across much of the U.S. Ten people were killed in Missouri after a tornado outbreak.

The threat of tornadoes in parts of the U.S. proved deadly as whipping winds moved east into the Mississippi Valley and Deep South on Saturday, with at least two people killed in south-central