Linaclotide, a guanylate cyclase C receptor agonist, has shown promising efficacy as a treatment for chronic constipation in a phase IIb, double-blinded, placebo-controlled, dose-ranging trial.
Bethesda, MD) for the treatment of chronic, idiopathic constipation in adults. In 2008, the FDA approved lubiprostone (Amitiza ®) for the treatment of constipation-predominant IBS in women ≥18 ...
Careful attention should be paid to clues that suggest chronic illnesses, such as diabetes, renal failure or hypothyroidism, as these often contribute to constipation in a number of ways.
The PROGRESS trial, which enrolled people with chronic migraine ... career and finances," Lipton said. "Having a treatment that can act quickly and effectively addresses a key need." ...