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严俊课题组发现糖基转移酶MGAT4A介导的TP53突变型子宫内膜癌恶性进展 ...
N-糖蛋白质组学进一步鉴定出葡萄糖转运蛋白GLUT1是被MGAT4A修饰的糖蛋白之一:MGAT4A催化形成的分支型N-糖链后续与Galectin-9结合后,能增加GLUT1蛋白在细胞膜上的分布,致使葡萄糖摄取升高。此外,我们还揭示了野生型p53通过三种抑癌性的miRNA(miR-34a、miR-449a和miR ...
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