In rats, this compound produced anti-hyperalgesia in inflammatory and neuropathic pain models. L-838,417 did not impair motor coordination, and although its maximum analgesic effect was comparable ...

We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...

including validated neuropathic pain disease models. In parallel with the submission, the company is conducting a neurotoxicity study, as required by the FDA’s written feedback, to support the ...

fully normalizing pain thresholds in validated neuropathic pain models. Furthermore, Ketamir-2 has shown a strong safety and toxicological profile, observed across cardiovascular, CNS, respiratory ...