In rats, this compound produced anti-hyperalgesia in inflammatory and neuropathic pain models. L-838,417 did not impair motor coordination, and although its maximum analgesic effect was comparable ...

We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...

Animal models are critical in improving our understanding of neuropathic pain processes, enabling the discovery and development of new pain management medicines. This study evaluated behavioral ...

including validated neuropathic pain disease models. In parallel with the submission, the company is conducting a neurotoxicity study, as required by the FDA’s written feedback, to support the ...

fully normalizing pain thresholds in validated neuropathic pain models. Furthermore, Ketamir-2 has shown a strong safety and toxicological profile, observed across cardiovascular, CNS, respiratory ...