Unknown; predicted pathogenic in silico (CADD>20).

The hotspot at chr3q28 sits between the GMNC and osteocrin (OSTN) genes. They are involved in DNA replication and dendritic ...

We are pleased to present exclusive short films from “The Alzheimer’s Project,” sponsored by HBO Documentary Films and the National Institute on Aging of the National Institutes of Health, with ...

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University of Maryland School of Medicine and Greenebaum Cancer Center ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

The APOE region or locus is a segment of DNA with several genes in close apposition, including APOE. Its boundaries are not strictly defined, spanning a stretch between 0.2 and 10 Mb long. In 5’ to 3’ ...

Sixty percent said they would take a disease-modifying treatment if it provided three additional years of independence, compared to 45 percent for a treatment offering six months. These numbers varied ...

Unknown. Multiple in silico algorithms yielded conflicting results.

Dennis J. Selkoe, M.D. The Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School. Co-Director, Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s ...

While all three genotypes of mice performed similarly to wild-type animals on multiple behavioral and spatial memory tests, they faltered in tests of working memory. APP-KI had a subtle deficit, which ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...