This study evaluated behavioral, biomarker, and imaging readouts in the mouse spared nerve injury (SNI) model of neuropathic pain. The work was performed to validate the model and identify ...
We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...
Cellular research indicates that neuropilin-1 plays a crucial role in pain signaling, presenting a potential pathway for ...
An investigational drug for multiple sclerosis from Io Therapeutics has restored leg mobility and myelin nerve coatings in mice, the biotech ... a common model for neuroinflammation in humans ...
Dietmar Thal, Prof. Bart De Strooper, and Dr. Sriram Balusu demonstrates they can indeed prevent loss of nerve cells in a mouse model of Alzheimer's using specific inhibitors. "Nerve cells die in ...
In a series of studies using mouse and human neurons, the researchers discovered a new receptor for nerve growth factor ... that target NRP1 in models of pain," said Bunnett.