For many years, platinum-based chemotherapy has been one of the mainstays for advanced testicular cancer. Painful peripheral neuropathy, especially in the hands and feet, is a common side effect.
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA ...
One, a 33-year-old man, developed confusion, diaphoresis, disorientation, agitation, and tachycardia after discontinuing gabapentin 3600 mg daily. He received benzodiazepines without benefit ...
[1] When used for neuropathy, gabapentin has been effective and well tolerated at total daily oral doses of 1800–3600 mg. Gabapentin is often initiated at a lower dosage and increased gradually ...